A groundbreaking patent pending platform for early cancer detection.

AOA Dx is pioneering the field of glycolipids

Tumor marker gangliosides are a novel class of biomarkers. Gangliosides are a subclass of sugar-containing glycolipids found in cell membranes. While gangliosides are present in all cells, tumor cells possess a distinct signature of gangliosides compared to normal cells. Originating in tumor tissue, these targets are stable and present throughout cancer formation, development, and relapse. Given their persistent and homogeneous expression almost exclusively in cancer, tumor marker gangliosides are promising targets to be exploited as biomarkers.

The GlycoLocate™ Platform is the future

The GlycoLocate™ platform will be the first of its kind to use tumor marker gangliosides as biomarkers to diagnose early-stage cancers by using a non-invasive blood test.

Early cancer detection,

Our AI-enabled GlycoLocate™ platform will be the first and only to harness the power of tumor marker gangliosides to detect cancer earlier, enabling more patients to get access to life-saving treatments sooner. The GlycoLocate™ platform may differentiate between cancers down to their tissue of origin in both symptomatic and non-symptomatic patients. This superior breakthrough technology removes the typical barriers of cost, invasiveness, accessibility, and effectiveness seen with current early detection technologies.

Glycomics of tumor marker gangliosides are the next frontier in early cancer detection

To date, genomics and proteomics have been used as tools in precision medicine. The active role of tumor marker gangliosides during cancer development makes them specific and etiological biomarkers of malignancy. AOA Dx foresees glycomics of tumor marker gangliosides as the next frontier used for diagnosis, prognosis, monitoring and ultimately targeted therapies. With many cancers, including ovarian, breast, lung, melanoma and neuroblastoma expressing these unique gangliosides in even the earliest stages, AOA Dx’s platform can be harnessed across a variety of indications. Identification of markers through the GlycoLocate™ platform will allow earlier and more accurate detection of cancer, changing the face of early cancer detection.

Ovarian cancer is just the start for AOA Dx and the GlycoLocate™ platform

Developing the platform in collaboration with leading world experts and scientists in conjunction with state-of-the-art data science, we believe we can change the paradigm of early diagnosis of many of the world’s deadliest cancers.

The GylcoLocate™ platform is changing the world of cancer detection to diagnose patients earlier and keep them with their loved ones longer. Find out how AKRIVIS GD™ is transforming women’s health through early ovarian cancer detection


Nejatie, A., Yee, S. S., Jeter, A. & Saragovi, H. U. The cancer glycocode as a family of diagnostic biomarkers, exemplified by tumor-associated gangliosides. Front Oncol 13, 1261090 (2023).

Yu, R. K., Tsai, Y. T., Ariga, T. & Yanagisawa, M. Structures, biosynthesis, and functions of gangliosides–an overview. J Oleo Sci60, 537-544 (2011).

Galan, A. et al. GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer.Front Oncol 13, 1134763 (2023).

Groux-Degroote, S., Rodriguez-Walker, M., Dewald, J. H., Daniotti, J. L. & Delannoy, P. Gangliosides in Cancer Cell Signaling.Prog Mol Biol Transl Sci 156, 197-227 (2018).

Caldwell, S. et al. Mechanisms of ganglioside inhibition of APC function. J Immunol 171, 1676-1683 (2003).

Tong, W., Maira, M., Gagnon, M. & Saragovi, H. U. Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology. PLoS One 10, e0134255 (2015).

Chen, Y. X. et al. Effect of tumor gangliosides on tyrosine phosphorylation of p125FAK in platelet adhesion to collagen. Oncology reports 29, 343-348 (2013).

Shibuya, H. et al. Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.Cancer Sci 103, 1656-1664 (2012).

Webb, T. J. et al. Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer. Cancer Res72, 3744-3752 (2012).

Orsi, G. et al. GD2 expression in breast cancer. Oncotarget 8, 31592-31600 (2017).

Liang, Y. J. et al. Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. Oncotarget 8, 47454-47473 (2017).

Yoshida, S. et al. Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. Cancer Res 61, 4244-4252 (2001).

Hamamura, K. et al. Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. J Biol Chem 286, 18526-18537 (2011).

Ladisch, S. et al. Shedding of GD2 ganglioside by human neuroblastoma. Int J Cancer 39, 73-76 (1987).

Balis, F. M. et al. The ganglioside G(D2) as a circulating tumor biomarker for neuroblastoma. Pediatr Blood Cancer 67, e28031 (2020).

Schulz, G. et al. Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res 44, 5914-5920 (1984).